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Biotin-PEG4-Picolyl azide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Biotin-PEG4-Picolyl azide图片
CAS NO:2222687-71-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
Biotin-PEG4-Picolyl azide 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。
Cas No.2222687-71-8
别名生物素-PEG4-甲基吡啶叠氮
Canonical SMILESO=C(NC1=CC=C(CN=[N+]=[N-])N=C1)CCOCCOCCOCCOCCNC(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O
分子式C27H42N8O7S
分子量622.74
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562