您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Implitapide
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Implitapide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Implitapide图片
CAS NO:177469-96-4
包装:5 mg
市场价:7000元

产品名称
英普他派
AEGR 427
产品介绍

产品描述

Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).

体外活性

Implitapide inhibits MTP activity using a recombinant human form complexed with protein disulphide isomerase (IC50=10 nM). Implitapide also inhibits the secretion of apoB-containing very low-density lipoprotein (VLDL)-like lipoproteins from a human hepatoma cell (HepG2) (IC50: 1.1 nM)[1].

体内活性

Implitapide (3.2 mg/kg/d) markedly inhibits lipid-stained lesions in the mice fed the western-type diet (WD). Implitapide (3.2 mg/kg/d) significantly decreases lesion area by 83% compared with that of the WD group (p<0.01). Implitapide (3.2 mg/kg/d) significantly decreases the plasma lipid levels to nearly or below the chow diet (CD) level at 4 and 8 weeks of treatment (p<0.01). Implitapide at a dosage of approximately 3.2 mg/kg/d significantly reduces the lipid-stained aortic lesions by 83% in apoE KO mice. ApoE KO mice fed a WD containing Implitapide (1, 5, and 15 mg/kg/d) for 14 weeks have been shown to reduce significantly both plaque area (by 66, 78, and 93%, respectively) and lipid moieties within plaque (4.3, 2.6, and 0%, respectively, versus 9.5% in controls)[1].

Cas No.

177469-96-4

分子式

C35H37N3O2

分子量

531.69

别名

英普他派;AEGR 427

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years