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Telotristat ethyl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Telotristat ethyl图片
CAS NO:1033805-22-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
LX1606
产品介绍
TelotriSTAT ethyl 是一种口服具有活力的色氨酸羟化酶抑制剂,可抑制血清素的产生。

产品描述

Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

体内活性

Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation[1]. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. However, Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT) nor alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis[2]. Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease.

Cas No.

1033805-22-9

分子式

C27H26ClF3N6O3

分子量

574.98

别名

LX1606

储存和溶解度

DMSO:98.5 mg/mL (171.31mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years