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PTUPB
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PTUPB图片
CAS NO:1287761-01-6
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。

产品描述

PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).

体外活性

PTUPB has minimal inhibitory effects on cell proliferation in multiple cancer cell lines, including human melanoma cell and a transformed endothelial cell, whereas it potently inhibits HUVEC proliferation after 3 days of application[1].

体内活性

PTUPB inhibits LLC tumor growth by 70-83% and exhibits with no overt toxicity, such as any weight loss when it is compared with the control group. After a period of treatment, the peak plasma concentration of PTUPB is high[1].

Cas No.

1287761-01-6

分子式

C26H24F3N5O3S

分子量

543.56

储存和溶解度

DMSO:100 mg/mL (183.97 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years