ZM223 是 NEDD8 活化酶 (NAE) 的抑制剂。

ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).

ZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex[1].

2031177-48-5

C23H17F3N4O2S2

502.53

ZM-223

DMSO:80 mg/mL (159.2 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years