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NH2-PEG2-C2-Boc
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NH2-PEG2-C2-Boc图片
CAS NO:756525-95-8
包装:100mg
市场价:450元

产品介绍
NH2-PEG2-C2-Boc是一种PROTAClinker,属于PEG类。NH2-PEG2-C2-Boc可用于合成PROTAC分子。NH2-PEG2-C2-Boc也是一种不可降解(non-cleavable)的含2个单元PEG的ADClinker,可用于合成抗体偶联药物(ADC)。
Cas No.756525-95-8
别名9-氨基-4,7-二氧杂壬酸叔丁酯
Canonical SMILESNCCOCCOCCC(OC(C)(C)C)=O
分子式C11H23NO4
分子量233.3
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[1]. Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 24;62(2):941-964. [2]. Joshua D. Thomas, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.