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MitoBloCK-10
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MitoBloCK-10图片
CAS NO:394694-98-5
包装与价格:
包装价格(元)
500μg电议
1mg电议

产品介绍
MitoBloCK-10(MB-10)是首个减弱PAM复合体活性的小分子调节剂。MitoBloCK-10(MB-10)可抑制C末端结构域的Tim44与前体和Hsp70结合。
Cas No.394694-98-5
别名3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼
Canonical SMILESO=C(N/N=C/C1=CC=C([N+]([O-])=O)S1)C2=CC=CC(F)=C2
分子式C12H8FN3O3S
分子量293.27
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70[1].

MB-10 (100 μM) is a potential attenuator of protein import into mitochondria[1].MB-10 inhibits the import of substrates that use the TIM23 import pathway[1].MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria[1]. Cell Viability Assay[1] Cell Line: A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains.

[1]. Non Miyata, et al. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31;292(13):5429-5442.