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Manool
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Manool图片
CAS NO:596-85-0
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
Manool是丹参中的二萜。Manool在癌细胞中诱导选择性的细胞毒性。Manool使癌细胞停滞在细胞周期的G(2)/M期。
Cas No.596-85-0
别名(4AR)-反式-5-(1,5,5,8AS-四甲基-2-亚甲基十氢-1-萘基)-(3R)-甲基-1-戊烯-3-醇
Canonical SMILESCC(CCC1)(C)[C@]([C@@]1(C)[C@H]2CC[C@](O)(C)C=C)([H])CCC2=C
分子式C20H34O
分子量290.48
储存条件4℃, stored under nitroge
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2].

Manool exhibits higher cytotoxic activity against HeLa (IC50=6.7 µg/mL) and U343 (IC50=6.7 µg/mL) cells[1].Manool exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells[3].

[1]. de Oliveira PF, et al. Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells. Cytotechnology. 2016;68(5):2139-2143. [2]. Pratsinis H, et al. Antiproliferative activity of Greek propolis. J Med Food. 2010;13(2):286-290. [3]. Nicolella HD, et al. Differential effect of manool--a diterpene from Salvia officinalis, on genotoxicity induced by methyl methanesulfonate in V79 and HepG2 cells. Food Chem Toxicol. 2014;72:8-12.