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NF 1819
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NF 1819图片
CAS NO:1881244-28-5
包装:10mg
市场价:2720元

产品介绍
NF 1819 是一种有效且选择性的不可逆 MGL(β;-内酰胺基单酰基甘油脂肪酶)抑制剂。
Cas No.1881244-28-5
Canonical SMILESFC1=CC=C([C@@H]2[C@@H](C3=CC=C4OCOC4=C3)N(C2=O)C5CCN(C(N6C=NC=N6)=O)CC5)C=C1
分子式C24H22FN5O4
分子量463.46
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective irreversible MAGL inhibitor (IC50 values are 0.25 and 7.4 nM at rMAGL and hMAGL, respectively). Exhibits 389-fold selectivity over hFAAH and exhibits minimal binding at CB receptors (IC50 > 10 μM). Alleviates symptoms in a MS in vivo model. Exhibits analgesic effects in an acute inflammatory pain model in vivo. Ameliorates neuropathic hypersensitivity induced by oxaliplatin . Displays high membrane permeability and brain penetrant.

Brindisi et al (20106) Development and pharmacological characterization of selective blockers of 2-arachidonoyl glycerol degradation with efficacy in rodent models of multiple sclerosis and pain. J.Med.Chem. 59 2612 PMID:26888301