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Ceefourin 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ceefourin 1图片
CAS NO:315702-40-0
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Ceefourin 1 是一种有效且高度选择性的多药耐药蛋白 4 (MRP4) 抑制剂。 Ceefourin 1 抑制多种 MRP4 底物的转运,但对 MRP4 的选择性高于其他 ABC 转运蛋白。 Ceefourin 1 是一种苯并噻唑,主要用作高危神经母细胞瘤的化学增敏剂。
Cas No.315702-40-0
Canonical SMILESCN1C(NN=C1CSC2=NC3=CC=CC=C3S2)=S
分子式C11H10N4S3
分子量294.42
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Selective MRP (multidrug resistance-associated protein) 4 inhibitor (IC50 = 2.6 μM). Selective for MRP4 over P-gp, MRP1 and ABCG2. Sensitizes MRP4 over-expressing cells to SN 38 .

Cheung et al (2014) High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem.Pharmacol. 91 97 PMID:24973542