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MDNI-caged-L-glutamate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MDNI-caged-L-glutamate图片
CAS NO:864085-92-7
包装:10mg
市场价:4452元

产品介绍
MDNI-caged-L-glutamate (MDNI-glu) 是主要兴奋性氨基酸 L-谷氨酸的一种生物惰性、光敏衍生物。
Cas No.864085-92-7
别名MDNI-glu
Canonical SMILESO=C(CC[C@H](N)C(O)=O)N1C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(OC)=C2CC1
分子式C14H16N4O8
分子量368.3
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Rapidly and efficiently releases glutamate when photolysed (350 - 365 nm excitation). Water soluble and stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to 200 μM). 5.5 times more photosensitive than MNI-caged L-glutamate . Laser activation of MDNI-glu evokes a rapid increase in intracellular Ca2+ concentration in astrocytes.

Fedoryak et al (2005) Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells. Chem. Commun. (Camb.) 7 3664 PMID:16027904 |Papageorgiou et al (2005) Synthetic and photochemical studies of substituted 1-acyl-7-nitroindolines. Photochem.Photobiol.Sci. 4 887 PMID:16252044 |Popovic et al (2015) Electrical behaviour of dendritic spines as revealed by voltage imaging. Nat.Commun. 6 8436 PMID:26436431