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Lenalidomide-OH
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lenalidomide-OH图片
CAS NO:1416990-08-3
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议
500mg电议

产品介绍
Lenalidomide-OH 是一种用于 E3 泛素连接酶的 cereblon (CRBN) 配体 Lenalidomide 的类似物，用于 CRBN 蛋白的募集。Lenalidomide-OH 可通过 linker 连接到蛋白质配体上形成 PROTAC，如 PROTAC BTK 降解剂 SJF620 。
Cas No.1416990-08-3
Canonical SMILESO=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O
分子式C13H12N2O4
分子量260.25
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 [1].

Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.