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Lidocaine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lidocaine hydrochloride图片
CAS NO:73-78-9
包装与价格:
包装价格(元)
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Xyloneural
Lignocaine hydrochloride
Lidocaine HCL
Lidothesin
盐酸利多卡因
产品介绍
LIDOcaine hydrochloride 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制MEK/ERK和NF-κB信号通路来减少胃癌细胞的生长,迁移和侵袭。LIDOcaine 是一种酰胺衍生物,是一种研究室性心律失常的药物和有效的肿瘤抑制剂。

产品描述

Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.

体外活性

Lidocaine above 1.25 g/l reduces cellular viability and triggers apoptosis in HCE cells in a time- and dose-dependent manner. Lidocaine-induced apoptosis is caspase dependent and may be related to mitochondrial pathway[1]. Lidocaine, at the level of tissue concentration under topical or local administration, also has a direct inhibitory effect on the activity of epidermal growth factor receptor (EGFR), which is a potential target for antiproliferation in cancer cells[3].

体内活性

Intravenous administration of the local anaesthetic lidocaine has been used to treat neuropathic pain for several decades and significantly improves postoperative pain associated with complex spine surgery and cholecystectomy. It is well established that lidocaine used for regional anaesthesia blocks impulses in peripheral nerves by inhibiting voltage-gated sodium (Na+) channels. Intravenous lidocaine has an analgesic effect on mechanical noxious response, decreases the spinal noxious response induced by peripheral pinch stimuli and the frequency of spontaneous excitatory postsynaptic currents(EPSCs) without changing their amplitude. It has no effect on spontaneous inhibitory postsynaptic currents and produces an outward current in SG neurons[2].

细胞实验

Cells at logarithmic phase are treated with lidocaine hydrochloride at concentrations (w/v) from 10 to 0.15625 g/l in step dilutions. HCE cells without lidocaine treatment are used as controls. The morphology and growing status of the cells are monitored every 4 hr.(Only for Reference)

Cas No.

73-78-9

分子式

C14H23ClN2O

分子量

270.8

别名

Xyloneural;Lignocaine hydrochloride;Lidocaine HCL;Lidothesin;盐酸利多卡因

储存和溶解度

Ethanol:54 mg/mL (199.41 mM)
DMSO:49 mg/mL(180.9 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years