PFE-360 是一种有效的选择性 LRRK2 激酶抑制剂，在体内的IC50值为 2.3 nM。

PFE-360 is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).

PFE-360 (4 mg/kg and 7.5 mg/kg, orally, BID, 10-12 weeks) treatment effectively reduces the LRRK2-pSer935/total LRRK2 ratio. It has no significant adverse effects[1].

1527475-61-1

C16H16N6O

308.34

PF-06685360

DMSO:10.2 mg/mL (33.08 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years