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JMS 17-2 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JMS 17-2 hydrochloride图片
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Canonical SMILESClC1=CC=C(C2CCN(CC2)CCCN3C(C4=CC=CN4C5=CC=CC=C35)=O)C=C1.Cl
分子式C25H26ClN3O.HCl
分子量456.41
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Chemokine CX3CR1 (fractalkine receptor) antagonist. Inhibits fractalkine-induced ERK phosphorylation and decreases migration of breast cancer cells in vitro. Also inhibits circulating tumor cells from seeding into bone and reduces overall tumor burden in a breast cancer metastasis model.

Shen et al (2016) Novel small-molecule CX3CR1 antagonist impairs metastatic seeding and colonization of breast cancer cells. Mol. Cancer Res. 14 518 PMID:27001765