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CBM 301940
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CBM 301940图片
CAS NO:902146-11-6
包装:10mg
市场价:2690元

产品介绍
Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
Cas No.902146-11-6
Canonical SMILESCC(NC(C1=NOC(C(C(F)(F)F)(C(F)(F)F)O)C1)=O)CC(OC(C)(C)C)=O
分子式C15H20F6N2O5
分子量422.32
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent malonyl-CoA decarboxylase (MCD) inhibitor (IC50 = 23 nM). Suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Improves cardiac function during reperfusion of ischemic isolated rat hearts. Orally bioavailable.

Dyck et al (2004) Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ.Res. 94 e78 PMID:15105298 |Cheng et al (2006) Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J.Med.Chem. 49 4055 PMID:16821767