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LP 922761
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LP 922761图片
CAS NO:1454808-95-7
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
LP 922761 是一种有效的、选择性的和口服活性的接头蛋白 2 相关激酶 1 (AAK1) 抑制剂,在酶和细胞试验中的 IC50 分别为 4.8 nM 和 7.6 nM。
Cas No.1454808-95-7
Canonical SMILESCN(C(OC(C)(C)C)=O)CCNC1=NN2C(C=C1)=NC=C2C3=CC=C(C(N)=O)C=C3
分子式C21H26N6O3
分子量410.47
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted.

Kostich et al (2016) Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain. J.Pharmacol.Exp.Ther. 358 371 PMID:27411717