您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > dBRD9
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
dBRD9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
dBRD9图片
CAS NO:2341840-98-8
包装:5mg
市场价:5660元

产品介绍

Potent and selective BRD9 degrading PROTAC

Cas No.2341840-98-8
Canonical SMILESCOC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN(CC(NCCOCCOCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)C.Cl.Cl
分子式C40H45N7O10.2HCl
分子量856.75
溶解度Water 17.14 mg/ml, DMSO 42.84 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PROTAC(R) composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . Potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines. PROTAC(R) is a registered trademark of Arvinas Operations, Inc., and is used under license.

Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID:28418626