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SPRi 3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SPRi 3图片
CAS NO:1292285-54-1
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
SPRi 3 (SPRi3) 是一种有效的 sepipterin reductase (SPR) 抑制剂。
Cas No.1292285-54-1
别名SPRi3
Canonical SMILESCOCC(NCCC1=C(NC2=CC=C(C=C12)O)C)=O
分子式C14H18N2O3
分子量262.3
溶解度DMSO: 100 mM,Ethanol: 100 mM
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+ T cells. Suppresses proliferation of human effector CD4+ T cells following stimulation. Reduces SPR activity in mouse primary cultures of sensory neurons (IC50 = 450 nM). Ameliorates colitis, suppressing the intestinal infiltration of T cells and other immune cells in vivo. Also reduces immune-cell infiltration into mouse lungs. Reduces neuropathic and inflammatory pain in mouse models.

Haruki et al (2016) Tetrahydrobiopterin biosynthesis as a potential target of the kynurenine pathway metabolite xanthurenic acid. J.Biol.Chem. 291 652 PMID:26565027 |Latremoliere et al (2015) Reduction of neuropathic and inflammatory pain through inhibition of the tetrahydrobiopterin pathway. Neuron 86 1393 PMID:26087165 |Cronin et al (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature 563 564 PMID:30405245