Prochlorperazine dimaleate salt

Molecular Weight (MW)	606.09
Formula	C20H24ClN3S.C8H8O8
CAS No.	84-02-6
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 74 mg/mL (122.1 mM)
Water: <1 mg/mL
Ethanol: 2 mg/mL (3.3 mM)
SMILES	CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(Cl)C=C24)CC1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O
Synonyms	Prochlorperazin, Compazine, Capazine, Stemetil; Prochlorperazine Dimaleate; Prochlorperazine dimaleate salt; Prochlorperazine maleate; Buccastem; Prochlorperazine Edisylate; Prochlorperazine Edisylate Salt; Prochlorperazine Maleate; Salt, Prochlorperazine Edisylate;

Molecular Weight (MW)

606.09

Formula

C20H24ClN3S.C8H8O8

CAS No.

84-02-6

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 74 mg/mL (122.1 mM)

Water: <1 mg/mL

Ethanol: 2 mg/mL (3.3 mM)

SMILES

CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(Cl)C=C24)CC1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O

Synonyms

Prochlorperazin, Compazine, Capazine, Stemetil; Prochlorperazine Dimaleate; Prochlorperazine dimaleate salt; Prochlorperazine maleate; Buccastem; Prochlorperazine Edisylate; Prochlorperazine Edisylate Salt; Prochlorperazine Maleate; Salt, Prochlorperazine Edisylate;

In Vitro	In vitro activity: Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy. Kinase Assay: Perphenazine is a typical antipsychotic drug, inhibits 5-HT2A receptor (5-HT2A), Alpha-1A adrenergic receptor (α1A), Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor (H1) with Ki of 5.6, 10, 0.765/0.13, 3.4, and 8 nM. IC50 value: 5.6 nM (Ki, 5-HT2A) 10 nM (Ki,α1A), 0.765/0.13 nM (Ki,D2/D3), 3.4 nM (Ki,D2L receptor), 8 nM (Ki,H1); Target: 5-HT2A,α1A,D2/D3, D2L receptor,H1 Cell Assay: Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.
In Vivo	Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole.
Animal model
Formulation & Dosage
References	Pharmacol Res. 2004 Sep;50(3):351-8; PLoS One. 2011;6(7):e22274.

In Vitro

In vitro activity: Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy.

Kinase Assay: Perphenazine is a typical antipsychotic drug, inhibits 5-HT2A receptor (5-HT2A), Alpha-1A adrenergic receptor (α1A), Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor (H1) with Ki of 5.6, 10, 0.765/0.13, 3.4, and 8 nM. IC50 value: 5.6 nM (Ki, 5-HT2A) 10 nM (Ki,α1A), 0.765/0.13 nM (Ki,D2/D3), 3.4 nM (Ki,D2L receptor), 8 nM (Ki,H1); Target: 5-HT2A,α1A,D2/D3, D2L receptor,H1

Cell Assay: Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.

In Vivo

Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole.

Animal model

Formulation & Dosage

References

Pharmacol Res. 2004 Sep;50(3):351-8; PLoS One. 2011;6(7):e22274.

CAS NO:	84-02-6
规格:	≥98%

包装	价格(元)
1g	电议
2g	电议
5g	电议
10g	电议
25g	电议