R(+)-IAA-94 是一种有效的氯离子 (Chloride channels) 通道阻滞剂。R(+)-IAA-94 抑制 Nef-sdAb19 相互作用,并与 Nef 结合。
产品描述
R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-IAA-94 inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef).
体外活性
IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins[1][2].
Cas No.
54197-31-8
分子式
C17H18Cl2O4
分子量
357.23
别名
R(+)-Methylindazone
储存和溶解度
DMSO:90mg/mL (251.9mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years