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Transdermal Peptide acetate(888486-23-5 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
TD 1 (peptide) acetate
产品介绍
Transdermal Peptide acetate(888486-23-5 free base) 是一种 11 个氨基酸的肽,与 Na+/K+-ATPase β 亚基 (ATP1B1) 结合,主要与 ATP1B1 的 C 端相互作用。透皮肽可以增强许多大分子的透皮传递。透皮肽 TD 1 酰胺是一种新型肽,旨在增强透皮药物传递。

产品描述

Transdermal Peptide (TD 1 peptide) acetate is a 11-amino acid peptide, binds toNa+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide can enhance the transdermal delivery of many macromolecules.Transdermal Peptide TD 1 Amide is novel peptide designed to enhance transdermal drug delivery.

体外活性

In the presence of Transdermal Peptide, because of the specific binding of Transdermal Peptide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin[1].

Cas No.

TP1033L

分子式

C42H68N14O18S2

分子量

1121.2

别名

TD 1 (peptide) acetate

储存和溶解度

DMSO:2.5 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years