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GlyH-101
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GlyH-101图片
CAS NO:328541-79-3
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
GlyH 101
产品介绍
GlyH-101 是一种可渗透入细胞的CFTR阻断剂,Ki为1.4 uM。

产品描述

GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.

体外活性

GlyH-101 reversibly inhibits CFTR Cl- conductance in<1 min. [1] In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. [2] In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents. [3]

体内活性

In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.[1]

Cas No.

328541-79-3

分子式

C19H15Br2N3O3

分子量

493.155

别名

GlyH 101

储存和溶解度

DMSO:49.3 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years