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SAR7334
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SAR7334图片
CAS NO:1333210-07-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
TRCP6-IN-1
产品介绍
SAR7334 是TRPC6特异性抑制剂,抑制 TRPC6 电流的IC50为 7.9 nM。

产品描述

SAR7334 is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).

体外活性

SAR7334 is an inhibitor of TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells(IC50s of 9.5, 282 and 226?nM)[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1?μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1].SAR7334 dose-dependently reduces TRPC6 currents (IC50 of 7.9?nM). SAR7334 (100?nM) substantially reduces TRPC6 currents[3].

体内活性

In isolated perfused lungs from mice, SAR7334 (10?mg/kg, p.o.) inhibits TRPC6-dependent acute HPV . SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].

Cas No.

1333210-07-3

分子式

C21H22ClN3O

分子量

367.87

别名

TRCP6-IN-1

储存和溶解度

DMSO:350 mg/mL (951.42 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years