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AS1269574
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AS1269574图片
CAS NO:330981-72-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
AS 1269574
产品介绍
AS 1269574 是口服有效的GPR119激动剂,在表达人 GPR119 的 HEK293 细胞中EC50为 2.5 μM。它激活 TRPA1 阳离子通道,刺激胰高血糖素样肽-1分泌。它仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。它在 2 型糖尿病的研究中具有价值。

产品描述

AS 1269574 is a potent, orally available GPR119 agonist. AS1269574 has the potential for the research of type 2 diabetes.

体外活性

AS1269574 had an EC(50) value of 2.5μM in HEK293 cells transiently expressing human GPR119 and enhanced insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8mM) conditions.?This contrasted with the action of the sulfonylurea glibenclamide, which also induced insulin secretion under low-glucose conditions (2.8mM)[1].

体内活性

In in vivo studies, a single administration of AS1269574 to normal mice reduced blood glucose levels after oral glucose loading based on the observed insulin secretion profiles.?Significantly, AS1269574 did not affect fed and fasting plasma glucose levels in normal mice.?AS1269574 represents a novel structural class of small molecule, orally administrable GPR119 agonists with GSIS and promising potential for the treatment of type 2 diabetes[1].

Cas No.

330981-72-1

分子式

C13H14BrN3O

分子量

308.18

别名

AS 1269574

储存和溶解度

DMSO:250 mg/mL (811.24 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years