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Imanixil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Imanixil图片
CAS NO:75689-93-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议

产品介绍
Imanixil (HOE-402 free base) 是 LDL 受体 (LDLR) 的诱导剂。Imanixil (HOE-402 free base) 也是一种有效的降胆固醇化合物,可抑制极低密度脂蛋白 (VLDL) 的产生,从而减弱动脉粥样硬化的发展。
Cas No.75689-93-9
别名伊马昔尔,HOE-402(free base)
Canonical SMILESO=C(C1=CN=C(N2CC(C)(C)NC2=O)N=C1N)NC3=CC=CC(C(F)(F)F)=C3
分子式C17H17F3N6O2
分子量394.35
溶解度DMSO: 300 mg/mL (760.75 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Imanixil (HOE-402 free base) is an inducer of the LDL receptor (LDLR). Imanixil (HOE-402 free base) is also a potent cholesterol-lowering compound, which inhibits very low density-lipoprotein (VLDL) production, and consequently attenuates atherosclerosis development[1].

[1]. Draijer R, et al. HOE 402 lowers serum cholesterol levels by reducing VLDL-lipid production, and not by induction of the LDL receptor, and reduces atherosclerosis in wild-type and LDL receptor-deficient mice. Biochem Pharmacol. 2002 May 1;63(9):1755-61.