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ATN-161 trifluoroacetate salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ATN-161 trifluoroacetate salt图片
CAS NO:904763-27-5
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
ATN-161 TFA salt
产品介绍
ATN-161 trifluoroacetate salt 是一种新型整合素 α5β1 拮抗剂,可在小鼠模型中抑制血管生成和肝转移瘤的生长。

产品描述

ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases and improves survival in a murine model.

体外活性

The combination of ATN-161 plus 5-FU significantly reduces tumor cell proliferation compared to control and single-agent therapy. Moreover, combination therapy leads to a significant increase of apoptotic (TUNEL-positive) tumor cells, whereas single-agent therapy does not increase in TUNEL-positive tumor cells. ATN-161 treatment leads to a significant reduction in EC number (21% decrease) after a 48 hr incubation time than controls[1]. ATN-161 inhibits VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. ATN-161 decreases the number of cells migrating in response to VEGF in a dose-dependent manner starting at 100 nM (P<0.001 vs. VEGF group) [2].

体内活性

The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) demonstrate that treatment with ATN-161 significantly reduces tumor weight and vessel density [1]. Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564 [2].

Cas No.

904763-27-5

分子式

C25H36F3N9O10S

分子量

711.67

别名

ATN-161 TFA salt

储存和溶解度

DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years