Mps1-IN-3 是一种有效的选择性 MPS1 激酶抑制剂，IC50值为 50 nM。

Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).

Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells (IC50: appr 5 μM). Mps1-IN-3 is an effective inhibitor of MPS1 kinase (IC50: 50 nM). Mps1-IN-3 (2 μM) can completely abrogates checkpoint.

Mps1-IN-3 (2 mg/kg, i.v.) sensitizes glioblastoma cells in murine tumor models. It has prolonged survival and no toxicity.

1609584-72-6

C26H31N7O4S

537.63

DMSO:5 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years