您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > ARQ 621
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
ARQ 621
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ARQ 621图片
CAS NO:1095253-39-6
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品介绍
ARQ 621 是一种变构和选择性 Eg5 有丝分裂运动蛋白抑制剂,具有抗肿瘤活性。

产品描述

ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.

体外活性

ARQ 621 demonstrates anti-tumor activity against a wide range of human cancer cell lines in vitro, including colon, lung, endometrial, bladder, and hematologic cancer cell lines, with significantly less cytotoxicity against hematopoietic cells. [1]

体内活性

ARQ 621, as a novel clinical stage drug candidate, inhibits a number of xenografts grown in athymic mice, such as pancreatic, breast, prostate, and ovarian carcinomas with no hematological changes. Furthermore, for ARQ 621, there is no envidence of bone marrow toxicity in pre-clinical mouse efficacy models or safety studies in rats and dogs. [1]

Cas No.

1095253-39-6

分子式

C28H24Cl2FN5O2

分子量

552.43

储存和溶解度

H2O:<1 mgml
Ethanol:93 mg/mL (168.3 mM)
DMSO:93 mg/mL (168.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years