E 64c 是一种不可逆且可透过膜的半胱氨酸蛋白酶抑制剂，是 E-64 的衍生物。它也是钙离子激活中性蛋白酶抑制剂和组织蛋白酶C弱不可逆抑制剂，可抑制 MERS-CoV。

Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.

Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. [1]E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease. [4]

In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. [2] E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. [3]

76684-89-4

C15H26N2O5

314.382

阿洛司他丁酸;EP 475;NSC 694279;Loxistatin Acid

H2O:2 mg/mL (6.36 mM)
DMSO:58 mg/mL (184.5 mM)
Ethanol:58 mg/mL (184.5 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years