Tigecycline是甘氨酰环素抗生素，对Acinetobacter baumannii(A. baumannii) 的 MIC50和 MIC90分别为 1 和 2 mg/L。它对E. coli(MG1655 菌株) 的平均抑制浓度 (MIC) 约 125 ng/ mL。

Tigecycline is a broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex.

在患有骨髓炎的兔子模型中,Tigecycline能够抑制耐甲氧西林的金黄色葡萄球菌.在患有嗜肺军团菌肺炎的豚鼠体内,Tigecycline能够抗嗜肺军团菌.

Tigecycline是四环素特异性外排泵的底物,对多种有氧和厌氧细菌表现出抗菌活性。对于肠球菌,葡萄球菌和链球菌（MIC=0.06-0.25 mg / L）,Tigecycline能够产生抑菌作用。

220620-09-7

C29H39N5O8

585.658

GAR-936;替加环素

H2O:92 mg/mL (157.1 mM)
Ethanol:<1 mgml
DMSO:93 mg/mL (158.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years