Fiacitabine是单纯疱疹病毒 (HSV) DNA 复制的选择性抑制剂，对HSV1和HSV2的IC50分别为2.5 nM和12.6 nM。

Fiacitabine is a selective inhibitor of DNA replication of the herpes simplex virus(HSV) (IC50: 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively).

FIAC was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloguanosine and slightly more toxic to normal cells. FIAC was about 8,000 times more active against the replication of wild-type herpes simplex virus type 1 than against a mutant strain lacking the expression of a virus-specified thymidine kinase. HSV FIAC suppressed by 90% the replication of various strains of herpes simplex virus types 1 and 2 at concentrations of 0.0025 to 0.0126 microM. Cytotoxicity was minimal, as determined by trypan blue dye exclusion with norman Vero, WI-38, and NC-37 cell proliferation; the 50% inhibitory dose was 4 to 10 microM in a 4-day assay [2].

69123-90-6

C9H11FIN3O4

371.1

NSC 382097;非西他滨;FIAC;FOAC

DMSO:35 mg/mL (94.31 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years