Gefitinib impurity 2

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CAS NO:	246512-44-7
包装:	5mg
市场价:	2250元

产品介绍

Gefitinibimpurity2是Gefitinib的杂质。Gefitinib是一种有效的，具有口服活性的选择性EGFR酪氨酸激酶抑制剂，IC50为33nM。Gefitinib选择性抑制EGF刺激的肿瘤细胞生长(IC50为54nM)，并阻断EGF刺激的肿瘤细胞中EGFR自磷酸化。Gefitinib还可诱导细胞自噬(autophagy)。Gefitinib具有抗肿瘤活性。

Cas No.	246512-44-7
别名	吉非替尼杂质
Canonical SMILES	O=C(N)C1=CC(OCCCN2CCOCC2)=C(OC)C=C1N
分子式	C₁₅H₂₃N₃O₄
分子量	309.36
储存条件	Store at -20℃
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2]. [1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54. [2]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23.