Pimpinellin 是贯众的一种成分，可通过诱导肿瘤细胞凋亡抑制肿瘤细胞的生长，可作为具有 GABA 受体活性的蛋白质的拮抗剂。

Pimpinellin is a natural product that acts as antagonist of proteins with GABA receptor activity.

Pimpinellin had potent cytotoxic activities against the three cell lines, with the IC50 values of 14.4?±?0.3?μM, 20.4?±?0.5?μM, and 29.2?±?0.6?μM, respectively. The mechanism of the antitumor action indicated that pimpinellin inhibited the growth of MGC-803 cells via the induction of tumor cell apoptosis, with apoptosis ratio of 27.44% after 72?h of treatment at 20?μM.

131-12-4

C13H10O5

246.218

DMSO:49 mg/mL (199.0 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years