Propylthiouracil 是一种甲状腺过氧化物酶抑制剂，也是一种5'-脱碘酶抑制剂。

Propylthiouracil is a thiourea derivative with an antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triiodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.

51-52-5

C7H10N2OS

170.23

6-Propyl-2-thiouracil;丙基硫氧嘧啶;6-n-Propylthiouracil;NSC 6498;Pseudocapsaicin;丙硫氧嘧啶;NSC 70461

Ethanol:16 mg/mL (94 mM)
DMSO:32 mg/mL (188 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years