O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyROSine 是一种有效的甲状腺激素,能够激活 β1 甲状腺激素受体 (TRβ1)。
产品描述
Liothyronine is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
体外活性
Triiodothyronine (0.01-0.1 μM) results in a decrease in the TRalpha1:TRalpha2 mRNA ratio in HepG2 cells. High liothyronine levels induces a low TRalpha1:TRalpha2 ratio which can protect the cell from excessive triiodothyronine-induced gene expression[1].
Cas No.
6893-02-3
分子式
C15H12I3NO4
分子量
650.97
别名
3,3',5-Triiodo-L-thyronine;Tresitope;Triiodothyronine;Lyothyronine;O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine;碘噻罗宁;L-3,3',5-Triiodothyronine;三碘甲状腺原氨酸
储存和溶解度
DMSO:91 mg/mL(139.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years