L-Thyroxine (T4)是一种合成的甲状腺激素,用于甲状腺功能减退症的研究。在DIO 酶作用下, L-Thyroxine (T4)转化成具有生物特性的三碘甲状腺氨酸 (T3)。
产品描述
Levothyroxine is the major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
Cas No.
51-48-9
分子式
C15H11I4NO4
分子量
776.874
别名
NSC 36397;T4;L-甲状腺素;Levothyroxine
储存和溶解度
DMSO:93 mg/mL (119.7 mM)
H2O:<1 mgml
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years