Liothyronine sodium 是甲状腺激素,能够结合并激活 β1 甲状腺激素受体。
产品描述
Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine sodium binds to nuclear thyroid receptors which then bind to thyroid hormone response elements of target genes. As a result, liothyronine sodium induces gene expression that is required for normal growth and development. Liothyronine sodium is more potent and has a more rapid action than thyroxine (T4).
体内活性
Liothyronine Sodium的化学性质几乎与三碘甲状腺氨酸一样,作用于甲状腺激素受体α和β-1。作为甲状腺激素的最有效形式,Liothyronine Sodium可使机体基础代谢率增加,影响蛋白合成,并且使机体对儿茶酚胺(如肾上腺素)敏感度增加。
Cas No.
55-06-1
分子式
C15H11I3NNaO4
分子量
672.959
别名
T3 Sodium salt;三碘代甲状腺素钠盐;Cytomel;Sodium L-3,3',5-triiodothyronine;3,3',5-Triiodo-L-thyronine sodium;Triostat
储存和溶解度
DMSO:33.6 mg/mL (50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years