CVN424 是一种有效的、具有口服活性的、选择性的GPR6反向激动剂,其EC50=9.4 nM,EC50=38 nM。它可以透过血脑屏障,对帕金森病具有潜在的研究价值。
产品描述
CVN424 is a selective and novel GPR6 Inverse agonist effective in models of Parkinson Disease.
体内活性
CVN424 is brain-penetrant and shows dose-dependent receptor occupancy that attained brain 50% of receptor occupancy at plasma concentrations of 6.0 and 7.4 ng/ml in mice and rats, respectively[1].
Cas No.
2254706-21-1
分子式
C24H29F2N5O3
分子量
473.52
储存和溶解度
DMSO:60mg/mL (126.71 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years