GLL 398 是一种具有口服活性的选择性雌激素受体降解剂，IC50 为 1.14 nM。 GLL 398 在异种移植乳腺癌模型中阻断肿瘤生长。

GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.

GLL398 exhibits a strong dose-dependent binding profile for the estrogen receptor with a Y537S point mutation with an IC50 of 29.5 nM[1].

2077980-80-2

DMSO:245 mg/mL (615.18 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years