Fadrozole 是一种有效的、非甾体类的、选择性的芳香化酶抑制剂(IC50:6.4 nM)。

Fadrozole is a nonsteroidal aromatase inhibitor with potential antineoplastic activity(IC50 : 6.4 nM)

Fadrozole is a model aromatase inhibitor that shown to suppress estrogen production in the ovaries of fish.

Adult female fathead minnows (Pimephales promelas) were exposed via water to 0, 5, or 50μg fadrozole/L for a time-course of 0.5, 1, 2, 4, and 6h, or 0 or 50μg fadrozole/L for a time-course of 6, 12, and 24h. Examined ex vivo ovarian 17β-estradiol (E2) and testosterone (T) production, and plasma E2 concentrations from each study.

102676-47-1

C14H13N3

223.279

DMSO:100 mg/mL (447.89 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years