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TAPI-1 trifluoroacetate(163847-77-6(free base))
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TAPI-1 trifluoroacetate(163847-77-6(free base))图片
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议

产品介绍
TAPI-1 trifluoroacetat 是一种 ADAM17/TACE 抑制剂,可阻断细胞因子受体的脱落。

产品描述

TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.

体外活性

TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. TAPI also inhibits LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes. TAPI-1 inhibits TACE-dependent constitutive release of co-transfected APP(695). TAPI-1 attenuates Ang II-induced EGFR transactivation and cell proliferation in human HSC line LI90. TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells.

Cas No.

T4122

分子式

C28H38F3N5O7

分子量

613.62

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years