CSF1R-IN-1 是一种 CSF1R 抑制剂 (IC50:0.5 nM)。

CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.

It is believed that CSF1R plays an important role in the recruitment and differentiation of tumor-associated macrophages (TAM). CSF1R-IN-1 showed good intestinal permeability in Caco2 analysis.

CSF1R-IN-1 has good pharmacokinetics when administered orally to mice. It seems suitable for in vivo pharmacological testing in an appropriate preclinical tumor model to prove a proof of concept.

2095849-04-8

C25H20F3N5O2

479.45

DMSO:83.33 mg/mL (173.80 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years