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DBCO-PEG4-acetic-Val-Cit-PAB
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DBCO-PEG4-acetic-Val-Cit-PAB图片
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
DBCO-PEG4-acetic-Val-Cit-PAB是一种可降解(cleavable)的含4个单元PEG的ADClinker,可用于合成抗体偶联药物(ADC)。
Canonical SMILESO=C(CCC(NCCOCCOCCOCC(N[C@@H](C(C)C)C(N[C@H](C(NC1=CC=C(CO)C=C1)=O)CCCNC(N)=O)=O)=O)=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
分子式C45H57N7O10
分子量855.97
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DBCO-PEG4-acetic-Val-Cit-PAB is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.