TL 13-112

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TL 13-112

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	2229037-19-6
包装:	5mg
市场价:	5395元

产品介绍

TL 13-112 是一种有效的选择性 ALK-PROTAC 降解剂，抑制 ALK 活性，IC50 值为 0.14 nM。 TL 13-112 还促进其他激酶的降解，包括 Aurora A、FER、PTK2 和 RPS6KA1，IC50 值分别为 8550 nM、42.4 nM、25.4 nM 和 677 nM。 TL 13-112 由色瑞替尼和 Pomalidomide 的 Cereblon 配体的结合物组成。

Cas No.	2229037-19-6
Canonical SMILES	CC(OC1=CC(C2CCN(CC2)CCOCCOCCNC(CNC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)=C(C=C1NC6=NC=C(C(NC7=CC=CC=C7S(=O)(C(C)C)=O)=N6)Cl)C)C
分子式	C₄₉H₆₀ClN₉O₁₀S
分子量	1002.57
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Selective anaplastic lymphoma kinase (ALK) degrader (DC50 values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h. Negative control TL 13-110 also available. Powell et al (2019) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 61 4249 PMID:29660984