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DPNB-ABT 594
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DPNB-ABT 594图片
包装:5mg
市场价:3660元

产品介绍
Caged ABT 594; suitable for one- or two-photon photolysis
Canonical SMILESClC1=NC=C(C=C1)OC[C@@H]2CCN2C(C)C3=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C3[N+]([O-])=O
分子式C31H46ClN3O11
分子量672.16
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nitrobenzyl-caged ABT 594 , a selective α4β2 nAChR agonist. One-photon uncaging evokes large inward currents and Ca2+ transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices. Two-photon uncaging induces fast nAChR-mediated currents. Photolyzed with high quantum yield of 0.20. Effective photolysis occurs using one- or two-photon excitation; one-photon uncaging requires illumination at 410 nm for 1.5-3 ms; two-photon uncaging requires illumination with appropriate two photon pulse laser at 710 nm for ~2 ms.

Passlick et al (2018) Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue. J.Physiol. 596 5307 PMID:30222192