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PA Nic
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PA Nic图片
包装:500 ug
市场价:6733元

产品介绍
Caged nicotine; photoactivated by one-photon and two-photon excitation
Canonical SMILESC[N@@+]1(CC2=CC(OC3=C2C=CC(N(CC(O)=O)CC(O)=O)=C3)=O)CCC[C@H]1C4=CC=CN=C4.OC(C(F)(F)F)=O.[O-]C(C(F)(F)F)=O
分子式C24H26N3O6.C2F3O2.C2HF3O2
分子量679.52
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Coumarin-caged nicotine. Releases nicotine when exposed to 390 ± 10 nm wavelength light (λmax = 404 nm). Suitable for two-photon uncaging at<900 nm (Maximum two-photon cross-section at 810 nm). Extinction coefficient (ε) 17,400 M-1cm-1. Evokes nicotinic currents in mouse brain slices under one and two-photon activation conditions.

Banala et al (2018) Photoactivatable drugs for nicotinic optopharmacology. Nat.Methods 15 347 PMID:29578537 |Yan et al (2018) Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission. Cell Rep. 23 2236 PMID:29791835 |Arvin et al (2019) Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine. J.Vis.Exp. 143 e58873 PMID:30735191