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LP 922056
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LP 922056图片
CAS NO:1365060-22-5
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
LP 922056 是一种具有口服活性的高效 Notum Pectinacetylesterase 抑制剂,在人和小鼠细胞试验中的 EC50 分别为 21 nM 和 55 nM。
Cas No.1365060-22-5
Canonical SMILESOC(CSC1=C2SC(Cl)=C(C2=NC=N1)C3CC3)=O
分子式C11H9ClN2O2S2
分子量300.78
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Notum pectinacetylesterase inhibitor. Activates wnt signalling in vitro (EC50 values are 21 nM in human and 55 nM in mouse cell-based assay). Increases cortical bone thickness in mouse model of bone growth.

Tarver et al (2016) Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg.Med.Chem.Lett 26 1525 PMID:26897593 |Brommage et al (2019) NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 7 PMID:30622831