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Pomalidomide 4'-PEG2-amine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Pomalidomide 4'-PEG2-amine图片
CAS NO:2245697-87-2
包装:25mg
市场价:1999元

产品介绍
Pomalidomide 4'-PEG2-amine 是一种合成的 E3 连接酶配体-接头偶联物，它包含基于 Thalidomide 的 cereblon 配体和用于 PROTAC 技术的 2 单元 PEG 接头。
Cas No.2245697-87-2
别名Thalidomide-NH-PEG2-C2-NH2 hydrochloride
Canonical SMILESNCCOCCOCCNC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O.Cl
分子式C19H24N4O6.HCl
分子量440.88
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG2 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Pomalidomide - linker 1 PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID:28418626