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PI4KIIIbeta-IN-10
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PI4KIIIbeta-IN-10图片
CAS NO:1881233-39-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
PI4KIIIbeta-IN-10 是PI4KIIIβ抑制剂,IC50=3.6 nM。

产品描述

PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).

体外活性

The most potent of these molecules (PI4KIIIbeta-IN-10;compound 10) was screened over a panel of nine related lipid kinases and was >200 fold selective for PI4KIIIβ across all enzymes tested.?Two of the most potent and selective molecules (compound 9+10) were also the most effective antiviral compounds in a cellular model of Hepatitis C virus replication, with the best balance of antiviral potency and low cellular toxicity.?PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and<20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ[1].

Cas No.

1881233-39-1

分子式

C22H25N3O5S2

分子量

475.58

储存和溶解度

DMSO:30 mg/mL (63.08 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years